Winston NatNeuro2002

From CogNeuroNotes

JS Winston, BA Strange, JO'Doherty, RJ Dolan (2002), Automatic and intentional brain responses during evaluation of trustworthiness of faces. Nature Neuroscience, 5, 277-283.

Contents 1 Task 2 Conditions 3 Results 3.1 Explicit > Implicit Judgment (regardless of trustworthiness) 3.2 Untrustworthy > Trustworthy 3.3 Interaction of Task X Trustworthiness 4 Tables

Task

See 60 faces for 1 sec each. Decide whether the face is a high school or university student. Press a button to respond.

See 60 faces for 1 sec each. Judge whether the face is trustworthy or untrustworthy. Press a button to respond.

Conditions

2 x 2 design

• Explicit vs Implicit : judge trustworthiness or age
• Untrustworthy vs Trustworthy : trustworthiness of face

Results

Explicit > Implicit Judgment (regardless of trustworthiness)

• R posterior STS (56,-44,4)
• primary visual cortex

Untrustworthy > Trustworthy

• bilateral Amygdala (18,0,-24)(-16,-4,-20)
• L STS (-50,-58,10) (driven mainly by explicit task)
• Right sup mid Insula (42,-4,12)
• bil FFG (44,-46,-24)(-48,-48,-24)

Interaction of Task X Trustworthiness

• Lateral orbiotfrontal cortex (-28,42,10) responded to untrustworthy faces in the implicit task and to trustworthy faces in the explicit task

(however it did not survive correction for multiple comparisons across the entire volume of orbitofrontal cortex)

Tables

Table 1. Cerebral foci of activation in main effect of task.

Brain region x y z Coordinates of peak activation (mm) Z score

Explicit versus implicit

Primary visual cortex 2 –98 8 4.49

Right posterior STS* 56 –44 4 4.27

Right superior frontal gyrus 10 14 70 3.99

Left premotor cortex –48 –2 26 3.84

Left extrastriate cortex –24 –76 32 3.75

Right cuneus 12 –40 56 3.62

Left primary sensory cortex –30 –28 72 3.62

Supramarginal gyrus –62 –40 34 3.50

Right anterior insula 48 34 –6 3.37

Left superior frontal sulcus –42 12 40 3.34

Left pre-SMA –6 10 54 3.34

Implicit versus explicit

Left fusiform gyrus –36 –36 –18 3.59

Right cuneus 4 –64 12 3.49

All values, p < 0.001 uncorrected. *p < 0.05 corrected for multiple comparisons across a small volume of interest.

Table 2. Cerebral foci of activation in differential effects of trustworthiness of faces.

Brain region x y z Coordinates of peak activation (mm) Z score

Untrustworthy versus trustworthy

Right amygdala* 18 0 –24 4.29

Left superior temporal sulcus –50 –58 10 4.15

Right intraparietal sulcus 22 –54 48 4.00

Left extrastriate cortex –34 –90 24 3.94

Left amygdala* –16 –4 –20 3.92

Right pre-SMA 8 8 62 3.83

Left parahippocampal gyrus –18 –30 –18 3.81

Right auditory cortex 66 –18 4 3.75

Left inferior temporal gyrus –60 –14 –30 3.64

Left fusiform gyrus* –48 –48 –24 3.60

Right fusiform gyrus* 44 –46 –22 3.58

Thalamus 4 –12 14 3.52

Right insula 42 –4 12 3.48

Left superior temporal gyrus –58 –32 14 3.42

Trustworthy versus untrustworthy

Left insula –36 4 –4 3.65

Right dorsolateral prefrontal/

frontopolar cortex 34 52 6 3.23

All values, p < 0.001 uncorrected. *p < 0.05 corrected for multiple comparisons across a small volume of interest